貨號	規(guī)格	價格	上海	北京	武漢	南京	購買數(shù)量
S84290-2mg	≥98%	￥990.00 S84290-2mg ￥990.00 2-3天	0 貨期：2-3天	-	-	-
S84290-5mg	≥98%	￥1500.00 S84290-5mg ￥1500.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 21 nM, 14 nM, 7.8 μM, 8.2 μM, 170 nM, 990 nM, 22 μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors, respectively

產(chǎn)品描述：

靶點：

mGluR1a:7.8 μM (IC50);mGluR2:21 nM (IC50);mGluR3:14 nM (IC50);mGluR4:22 μM (IC50);mGluR5a:8.2 μM (IC50);mGluR7:990 nM (IC50);mGluR8:170 nM (IC50);GluR

體內(nèi)研究：

LY341495 (0.3, 1, and 3 mg/kg, i.p.) displays a lower level of discrimination in rats. LY341495 (3.0 mg/kg) decreases Dvl-2, pGSK-3α/β and β-catenin protein levels but Dvl-1, Dvl-3 and GSK-3α/β are unaffected in both the PFC and STR. LY341495 has the generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist, LY379268. LY341495 (3 mg/kg, i.p., 2.5 h) -induced c-Fos expression is not altered in either KO brain. LY341495 is almost inactive in the central extended amygdala [central nucleus of the amygdala, lateral (CeL) and bed nucleus of the stria terminalis, laterodorsal (BSTLD)] in mGluR3-KO mice

參考文獻：

1. Pitsikas N, et al. The metabotropic glutamate 2/3 receptor antagonist LY341495 differentially affects recognition memory in rats. Behav Brain Res. 2012 May 1;230(2):374-9. 2. Sutton LP, et al. Regulation of Akt and Wnt signaling by the group II metabotropic glutamate receptor antagonist LY341495 and agonist LY379268.J Neurochem. 2011 Jun;117(6):973-83. 3. Linden AM, et al. Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495. Neuropharmacology. 2009 Aug;57(2):172-82. Epub 2009 May 27. 4. Li J, et al. N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases. Pain. 2016 Aug;157(8):1711-23. 5. A E Kingston, et al. LY341495 Is a Nanomolar Potent and Selective Antagonist of Group II Metabotropic Glutamate Receptors.Neuropharmacology. 1998;37(1):1-12.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.83 ml	14.149 ml	28.298 ml
5 mM	0.566 ml	2.83 ml	5.66 ml
10 mM	0.283 ml	1.415 ml	2.83 ml
50 mM	0.057 ml	0.283 ml	0.566 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

質(zhì)檢證書(COA)

輸入產(chǎn)品批號：

如何獲取質(zhì)檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標(biāo)簽上如何找到貨號和批號?

摩爾濃度計算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計算重置

国产精品+调教,sao货水真多把你cao烂动态,小说女频修仙,被合租刑警的粗汉肉h高np,波多官能人小说电影番号,我的姐夫是太子小说全集完整版txt,男生和女生一起差差差很痛的app下载,午夜福利日本精品,亲嘴一边揉一边往下摸视频