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Daclatasvir (BMS-790052)

    
99%

Daclatasvir (BMS-790052)

源葉(MedMol)
S81646 一鍵復(fù)制產(chǎn)品信息
1009119-64-5
C40H50N8O6
738.89
達(dá)卡他韋;N,N'-[[1,1'-聯(lián)苯]-4,4'-二基雙[1H-咪唑-5,2-二基-(2S)-2,1-吡咯烷二基 [(1S)-1-(1-甲基乙基)-2-氧代-2,1-乙烷二基]]]雙氨基甲酸 C,C'-二甲酯
貨號(hào) 規(guī)格 價(jià)格 上海 北京 武漢 南京 購(gòu)買數(shù)量
S81646-5mg 99% ￥495.00 >10 - - -
S81646-10mg 99% ￥750.00 >10 - - -
S81646-50mg 99% ￥3100.00 >10 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 μM and 3.27 μM, respectively[1]

產(chǎn)品描述： Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 μM and 3.27 μM, respectively[1]
靶點(diǎn)： EC50: 50 pM (HCV replicon genotype 1a), 9?pM (HCV replicon genotype 1b), 71 pM (HCV replicon genotype 2a), 146 pM (HCV replicon genotype 3a), 12 pM (HCV replicon genotype 4a) and 33 pM (HCV replicon genotype 5a) Kd: 8 nM (NS5A33-202) and 210 nM (NS5A26-202) IC50: 1.5 μM (OATP1B) and 3.27 μM (OATP1B3);HCVProtease
體內(nèi)研究： Daclatasvir (BMS-790052; 30?mg/kg; oral administration; daily; for 27 days) treatment reduces serum HCV RNA titers very rapidly by ~1.5 log10 at day 3
參考文獻(xiàn)： 1. Min Gao, et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature. 2010 May 6;465(7294):96-100. 2. David B Ascher, et al. Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA. Sci Rep. 2014 Apr 23;4:4765. 3. Tomomi Furihata, et al. Different interaction profiles of direct-acting anti-hepatitis C virus agents with human organic anion transporting polypeptides. Antimicrob Agents Chemother. 2014 Aug;58(8):4555-64. 4. Seung-Hoon Lee, et al. HA1077 displays synergistic activity with daclatasvir against hepatitis C virus and suppresses the emergence of NS5A resistance-associated substitutions in mice. Sci Rep. 2018 Aug 20;8(1):12469.
溶解性： Soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 1.353 ml 6.767 ml 13.534 ml
5 mM 0.271 ml 1.353 ml 2.707 ml
10 mM 0.135 ml 0.677 ml 1.353 ml
50 mM 0.027 ml 0.135 ml 0.271 ml
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參考文獻(xiàn)

質(zhì)檢證書(COA)

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摩爾濃度計(jì)算器

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