貨號	規(guī)格	價格	上海	北京	武漢	南京
S81441-5mg	98.6%	￥280.00 S81441-5mg ￥280.00 現(xiàn)貨	10 10	-	-	-
S81441-10mg	98.6%	￥550.00 S81441-10mg ￥550.00 現(xiàn)貨	16 >10	-	-	-
S81441-100mg	98.6%	￥2520.00 S81441-100mg ￥2520.00 現(xiàn)貨	7 7	-	-	-

產(chǎn)品介紹

Protirelin is a tripeptide that stimulates the release of thyrotropin and prolactin.

產(chǎn)品描述：

Protirelin is a tripeptide that stimulates the release of thyrotropin and prolactin.

靶點：

Endogenous Metabolite;Thyroid hormone receptor(THR);Thyroidhormonereceptor(THR);?EndogenousMetabolite

體內(nèi)研究：

Protirelin (TRH) is an evolutionarily ancient neuropeptide, having its origin before the divergence of protostomes and deuterostomes. Protirelin may ancestrally have been involved in the control of postembryonic growth and reproduction. The effect of the thyrotropin-releasing hormone (Protirelin, TRH), one of the hypothalamic releasing hormones, on body temperature is investigated in the rat. Protirelin, in doses of 1, 5, 10 and 20 mg/kg, is injected intraperitoneally to male Wistar rats weighing 200-250 g. Protirelin causes a temporary rise in body temperature dose-dependently. The thyroidectomized rats injected 20 mg/kg of Protirelin which induces a significant hyperthermia in the sham-operated animals, fail to show a rise in body temperature. The present results suggest that a release of thyroid hormone might participate in the hyperthermic action of Protirelin.

動物實驗：

Protirelin (TRH tartRatse) is dissolved in physiological saline (Rats).RatsNinety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C

參考文獻：

1.Noda Y,etal.Hyperthermia induced by thyrotropin-releasing hormone (TRH, protirelin) in the rat.Kurume Med J. 1979;26(2):107-12. 2.Van Sinay E,etal.Evolutionarily conserved TRH neuropeptide pathway regulates growth in Caenorhabditis elegans.Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4065-E4074.

溶解性：

DMSO:67 mg/mL (184.9 mM) H2O:66 mg/mL (182.1 mM) Ethanol:67 mg/mL (184.9 mM)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.76 ml	13.798 ml	27.595 ml
5 mM	0.552 ml	2.76 ml	5.519 ml
10 mM	0.276 ml	1.38 ml	2.76 ml
50 mM	0.055 ml	0.276 ml	0.552 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. Shan, Tong, et al. "Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast." Clinical Medicine Research 9.1 (2020): 11.doi: 10.11648/j.cmr.20200901.13

質(zhì)檢證書(COA)

輸入產(chǎn)品批號：

如何獲取質(zhì)檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計算重置

国产精品+调教,sao货水真多把你cao烂动态,小说女频修仙,被合租刑警的粗汉肉h高np,波多官能人小说电影番号,我的姐夫是太子小说全集完整版txt,男生和女生一起差差差很痛的app下载,午夜福利日本精品,亲嘴一边揉一边往下摸视频

Trh

Trh