| 產(chǎn)品描述： | Glucagon (1-29), bovine, human, porcine is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis. Glucagon (1-29), bovine, human, porcine activates HNF4α and increases HNF4α phosphorylation |
| 靶點： |
GCGR;Others |
| 體內(nèi)研究： |
Low-dose (20 μg/kg) Glucagon increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice |
| 參考文獻： |
1. Song WJ, et al. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014 Apr 1;19(4):667-81. 2. Hirota K, et al. Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. J Biol Chem. 2003 Apr 11;278(15):13056-60. 3. Song KH, et al. Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in humanhepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis. Hepatology. 2006 Jan;43(1):117-25. 4. Capozzi ME, et al. Glucagon lowers glycemia when β-cells are active. JCI Insight. 2019 Jul 23;5. pii: 129954. |
| 溶解性： |
H2O : 6.67 mg/mL (1.92 mM; ultrasonic and adjust pH to 3 with HCl) DMSO : 2.5 mg/mL (0.72 mM; Need ultrasonic) |
| 保存條件： |
-20℃,避光 |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
0.287 ml |
1.436 ml |
2.871 ml |
| 5 mM |
0.057 ml |
0.287 ml |
0.574 ml |
| 10 mM |
0.029 ml |
0.144 ml |
0.287 ml |
| 50 mM |
0.006 ml |
0.029 ml |
0.057 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學(xué)品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京