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Methylene Blue

    
98%(T)

Methylene Blue

源葉(MedMol)
S80842 一鍵復(fù)制產(chǎn)品信息
61-73-4
C16H18ClN3S
319.85
MFCD00012111
亞甲基藍(lán);次甲基蘭;美藍(lán);美蘭;亞甲藍(lán);品藍(lán);亞甲基蘭;堿性藍(lán)9
貨號(hào) 規(guī)格 價(jià)格 上海 北京 武漢 南京 購(gòu)買數(shù)量
S80842-25mg 98%(T) ¥100.00 8 - - -
S80842-100mg 98%(T) ¥180.00 貨期:2-3天 - - -
S80842-500mg 98%(T) ¥450.00 1 - - -
產(chǎn)品介紹 參考文獻(xiàn)(28篇) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015)在色素內(nèi)鏡檢查中被作用染料。它能抑制tau蛋白絲的形成,IC50為1.9μM,同時(shí)還抑制可溶性鳥苷環(huán)化酶

產(chǎn)品描述: Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015)在色素內(nèi)鏡檢查中被作用染料。它能抑制tau蛋白絲的形成,IC50為1.9μM,同時(shí)還抑制可溶性鳥苷環(huán)化酶
靶點(diǎn): guanylate cyclase; Tau aggregation:1.9 μM;Guanylatecyclase;MicrotubuleAssociated;NOSynthase;Parasite;MonoamineOxidase
體外研究: Methylene Blue可能抑制NO合成酶或通過產(chǎn)生超氧陰離子,直接使一氧化氮失活。除了干擾一氧化氮換鳥苷酸途徑,Methylene Blue直接激活鈣離子依賴性的鉀通道來增強(qiáng)去甲腎上腺素從細(xì)胞內(nèi)的釋放
體內(nèi)研究: Methylene Blue抑制鳥苷酸環(huán)化酶,減少C-GMP和血管平滑松弛。當(dāng)進(jìn)行靜脈注射時(shí),亞甲藍(lán)在甲狀旁腺積累,從而在外科手術(shù)中借以其顏色來判斷這些內(nèi)部結(jié)構(gòu)。在嚙齒類的藥動(dòng)學(xué)實(shí)驗(yàn)揭示,血管內(nèi)進(jìn)行MB給藥將導(dǎo)致MB在中樞神經(jīng)細(xì)胞中迅速?gòu)V泛的積累
細(xì)胞實(shí)驗(yàn): Cell lines: 未成熟的成神經(jīng)細(xì)胞 Concentrations: 10 μM Incubation Time: 2 h Method: 從新生大鼠的室管膜下層分離出來的未成熟的成神經(jīng)細(xì)胞,在單細(xì)胞培養(yǎng)模型中,分化成γ氨基丁酸所介導(dǎo)神經(jīng)元,用此神經(jīng)元細(xì)胞用于后續(xù)實(shí)驗(yàn)。在體外實(shí)驗(yàn)中,第6天,用MB對(duì)細(xì)胞培養(yǎng)物進(jìn)行處理2h,處理完48小時(shí)后,檢測(cè)細(xì)胞樹突分枝結(jié)構(gòu)及生存情況
動(dòng)物實(shí)驗(yàn): Animal Models: Sprague- Dawley雄性大鼠 Dosages: 5 and 50 mg/kg Administration: 血管內(nèi)注射
參考文獻(xiàn): 1. Vutskits L, et al. Adverse effects of methylene blue on the central nervous system. Anesthesiology. 108(4):684-692. 2. Hochgr鋐e K, et al. Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Acta Neuropathol Commun. 2015, 3:25. 3. Masaki E, et al. Methylene blue, a soluble guanylyl cyclase inhibitor, reduces the sevoflurane minimum alveolar anesthetic concentration and decreases the brain cyclic guanosine monophosphate content in rats. Anesth Analg. 1999, 89(2):484-489. 4. Ginimuge PR, et al. Methylene blue: revisited. J Anaesthesiol Clin Pharmacol. 2010, 26(4):517-520.
溶解性: Soluble  in  DMSO、Ethanol、H2O
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 3.126 ml 15.632 ml 31.265 ml
5 mM 0.625 ml 3.126 ml 6.253 ml
10 mM 0.313 ml 1.563 ml 3.126 ml
50 mM 0.063 ml 0.313 ml 0.625 ml
注意: 部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。

參考文獻(xiàn)(28篇)

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摩爾濃度計(jì)算器

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