產(chǎn)品描述: | CK-636 is a cell permeable inhibitor of Arp2/3 complex, that could inhibit actin polymerization, with IC50 values of 4 μM, 24 μM and 32 μM for human, fission yeast and bovine, respectively. CK636 blocks cell migration. |
靶點: |
IC50: 4/24/32 μM (Human/fission yeast/bovine Arp2/3);MicrotubuleAssociated |
參考文獻(xiàn): |
1. Nolen BJ, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature. 2009 Aug 20;460(7258):1031-4. 2. Kwon KW, et al. Migration of T cells on surfaces containing complex nanotopography. PLoS One. 2013 Sep 12;8(9):e73960. 3. Liang Ma, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015 Jan;25(1):24-38. |
溶解性: |
DMSO : ≥ 49 mg/mL (172.30 mM) |
保存條件: |
2-8℃ |
配置溶液濃度參考: |
|
1mg |
5mg |
10mg |
1 mM |
3.516 ml |
17.582 ml |
35.164 ml |
5 mM |
0.703 ml |
3.516 ml |
7.033 ml |
10 mM |
0.352 ml |
1.758 ml |
3.516 ml |
50 mM |
0.07 ml |
0.352 ml |
0.703 ml |
|
注意: |
部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。 |