| 產(chǎn)品描述： | Pamidronic acid is a drug used to treat a broad spectrum of bone absorption diseases. |
| 靶點(diǎn)： |
Wnt, β-catenin;Wnt/beta-catenin |
| 體內(nèi)研究： |
Pamidronic acid can significantly inhibit and even reverse early osteoarthritic subchondral bone loss, thus alleviating the process of cartilaginous degeneration. The mechanisms involved may be associated with the upregulation of OPG expression, and downregulation of RANKL, MMP-9 and TLR-4 expression |
| 參考文獻(xiàn)： |
1. Ashton JA, et al. Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cellsfrom dogs. Am J Vet Res. 2005 May;66(5):885-91. 2. Xu Y, et al. Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro. J Oral Maxillofac Surg. 2017 Mar 22. 3. Lv Y, et al. Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits. BMC Musculoskelet Disord. 2014 Nov 6;15:370. |
| 溶解性： |
Soluble in DMSO、H2O |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
4.254 ml |
21.27 ml |
42.541 ml |
| 5 mM |
0.851 ml |
4.254 ml |
8.508 ml |
| 10 mM |
0.425 ml |
2.127 ml |
4.254 ml |
| 50 mM |
0.085 ml |
0.425 ml |
0.851 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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