貨號	規(guī)格	價格	上海	北京	武漢	南京
S80275-25mg	99.8%	￥240.00 S80275-25mg ￥240.00 現(xiàn)貨	803 >10	-	-	-
S80275-100mg	99.8%	￥368.00 S80275-100mg ￥368.00 現(xiàn)貨	206 >10	-	-	-
S80275-500mg	99.8%	￥592.00 S80275-500mg ￥592.00 現(xiàn)貨	46 >10	-	-	-

產(chǎn)品介紹

Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local anesthetic, with antipruritic effects

產(chǎn)品描述：

靶點：

H1 Receptor:1.01 mM (IC50);5-HTReceptor;HistamineReceptor

體內(nèi)研究：

Pheniramine maleate (1.75 μM; i.t.) exerts local anesthesia effect and results spinal block in rats

參考文獻(xiàn)：

1. Sharma A, et al. Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view. Curr Drug Metab. 2003 Apr;4(2):105-29. 2. Brown RD, et al. Alpha 1-adrenergic and H1-histamine receptor control of intracellular Ca2+ in a muscle cell line: the influence of prior agonist exposure on receptor responsiveness. Mol Pharmacol. 1986 Jun;29(6):531-9. 3. Jangi SM, et al. Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist. Oncol Res. 2004;14(7-8):363-72. 4. Hung CH, et al. Spinal anesthesia with diphenhydramine and pheniramine in rats. Eur J Pharmacol. 2011 Dec 30;673(1-3):20-4.

溶解性：

H2O : ≥ 38 mg/mL (106.62 mM)

保存條件：

-20°C

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.806 ml	14.028 ml	28.057 ml
5 mM	0.561 ml	2.806 ml	5.611 ml
10 mM	0.281 ml	1.403 ml	2.806 ml
50 mM	0.056 ml	0.281 ml	0.561 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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Pheniramine Maleate