貨號	規(guī)格	價(jià)格	上海	北京	武漢	南京	購買數(shù)量
B25580-100mg	分析標(biāo)準(zhǔn)品,HPLC≥98%	￥162.00 B25580-100mg ￥162.00 現(xiàn)貨	10 2 10	-	1	1

產(chǎn)品介紹

是一種口服有效、能透過血腦屏障的半合成四環(huán)素類抗生素。Minocycline hydrochloride 是一種缺氧誘導(dǎo)因子 (HIF-1α) 抑制劑。Minocycline hydrochloride 具有抗癌(anti-cancer)，抗炎(anti-inflammatory) 和谷氨酸 (glutamate) 拮抗作用。Minocycline hydrochloride 降低谷氨酸神經(jīng)傳遞，顯示神經(jīng)保護(hù)特性和抗抑郁作用。Minocycline hydrochloride 通過與細(xì)菌核糖體30S亞基結(jié)合，抑制細(xì)菌蛋白的合成，從而產(chǎn)生抑菌 (bacteriostatic) 作用。

熔點(diǎn)：	205-210° (d°C)
沸點(diǎn)：	659.4°C at 760mmHg
溶解性：	DMSO : 19.23 mg/mL (38.93 mM; Need ultrasonic) H2O : 10 mg/mL (20.25 mM; Need ultrasonic)
敏感性：	對光敏感
儲存條件：	2-8℃
注意：	部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(19篇)

19. [IF=13.3] Lidong Wu et al."Machine learning-enabled flexible luminescent sensor for non-destructive mapping antibiotics distribution on seafood."CHEMICAL ENGINEERING JOURNAL.2025 Mar;:161376 18. [IF=5.9] Xingdu Chen et al."Biotransformation of minocycline by a novel strain Kluyvera sp. DM13 isolated from municipal sludge: Performances, removal pathways, and toxicity."Journal of Environmental Sciences.2024 Jul;: 17. [IF=4.3] Pengfei Gao et al."A rapid solid-phase extraction purification combined with UPLCMS/MS used for simultaneous determination of eight tetracyclines and three metabolite in chicken and pork."JOURNAL OF FOOD COMPOSITION AND ANALYSIS".2024 Aug;132:106317 16. [IF=15.1] Meng-Yan Deng et al."Dexamethasone attenuates neuropathic pain through spinal microglial expression of dynorphin A via the cAMP/PKA/p38 MAPK/CREB signaling pathway."BRAIN BEHAVIOR AND IMMUNITY".2024 Jul;119:36 15. [IF=2.032] Xu Han et al."Minocycline induces tolerance to dendritic cell production probably by targeting the SOCS1/ TLR4/NF-κB signaling pathway."TRANSPLANT IMMUNOLOGY.2023 Aug;79:101856

14. [IF=9.043] Chun-Yan Le et al."Hinokitiol Selectively Enhances the Antibacterial Activity of Tetracyclines against Staphylococcus aureus."Microbiology Spectrum. 13. [IF=3.631] Zhiya Yang et al."5-aminolevulinic acid-photodynamic therapy ameliorates cutaneous granuloma by killing drug-resistant Mycobacterium marinum."Photodiagn Photodyn. 2022 Mar;:102839 12. [IF=3.093] Huang Sheng-Nan et al."Bulleyaconitine A Inhibits Visceral Nociception and Spinal Synaptic Plasticity through Stimulation of Microglial Release of Dynorphin A."Neural Plast. 2020;2020:1484087 11. [IF=3.575] Xueqi Tang et al."The GLP-1 receptor herbal agonist morroniside attenuates neuropathic pain via spinal microglial expression of IL-10 and β-endorphin."Biochem Bioph Res Co. 2020 Sep;530:494 10. [IF=3.599] Ma Le et al."Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses."Neural Plast. 2021;2021:9923537 9. [IF=4.223] Yuan et al."Efficient degradation of minocycline by natural bornite-activated hydrogen peroxide and persulfate: kinetics and mechanisms."Environmental Science And Pollution Research. 2021 Jul 22 8. [IF=4.545] Usman Ali et al."Low frequency electroacupuncture alleviates neuropathic pain by activation of spinal microglial IL-10/β-endorphin pathway."Biomed Pharmacother. 2020 May;125:109898 7. [IF=5.243] Le Ma et al."Spinal microglial β‐endorphin signaling mediates IL‐10 and exenatide‐induced inhibition of synaptic plasticity in neuropathic pain."Cns Neurosci Ther. 2021 Oct; 27(10): 1157–1172 6. [IF=5.81] Zhao Meng-Jing et al."Bulleyaconitine A Inhibits Morphine-Induced Withdrawal Symptoms, Conditioned Place Preference, and Locomotor Sensitization Via Microglial Dynorphin A Expression."Front Pharmacol. 2021 Feb;0:92 5. [IF=5.858] Meng-Yan Deng et al."Thalidomide alleviates neuropathic pain through microglial IL-10/β-endorphin signaling pathway."Biochem Pharmacol. 2021 Oct;192:114727 4. [IF=7.217] Khalil Ali Ahmad et al."Microglial IL-10 and β-endorphin expression mediates gabapentinoids antineuropathic pain."Brain Behav Immun. 2021 Jul;95:344 3. [IF=8.322] Apryani Evhy et al."The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors."J Neuroinflamm. 2020 Dec;17(1):1-18 2. [IF=4.36] Qian Huang et al."Concurrent bullatine A enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors."J Ethnopharmacol. 2017 Jan;196:151 1. [IF=6.17] Qian Huang et al."Cynandione A attenuates neuropathic pain through p38β MAPK-mediated spinal microglial expression of β-endorphin."Brain Behav Immun. 2017 May;62:64

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美滿霉素

Minocycline hydrochloride