94. [IF=3.1] Xuanxuan Zhou et al."Exploration of material basis: Chemical composition profile and metabolic profile in Xiao Jianzhong Granules."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2025 Aug;260:116793 93. [IF=1.5] Qian Xiaojing et al."Qualitative, Quantitative Analysis and Pharmacokinetic Study of Potentially Active Components of Huangxueyishen Decoction Based on UPLC-MS/MS."JOURNAL OF CHROMATOGRAPHIC SCIENCE.2025 Apr;63(4): 92. [IF=3.3] Lingxiao Zhang et al."Integration of network pharmacology and transcriptomics to explore the mechanism of isoliquiritigenin in treating heart failure induced by myocardial infarction."TOXICOLOGY AND APPLIED PHARMACOLOGY.2024 Nov;492:117114 91. [IF=3.5] Sisheng Zhang et al."CcCHIL, a type IV chalcone isomerase that can improve (2S)-naringenin production in Saccharomyces cerevisiae."FOOD AND BIOPRODUCTS PROCESSING.2024 Dec;148:229 90. [IF=2.8] Hongbin Zhang et al."Rapid identification of chemical components and screening of acetylcholinesterase inhibitors from Dalbergia odorifera based on mass defect and diagnostic ion filtering strategy, affinity ultrafiltration, and liquid chromatography-tand 89. [IF=5.4] Weiliang Fu et al."Network pharmacology combined with affinity ultrafiltration to elucidate the potential compounds of Shaoyao Gancao Fuzi Decoction for the treatment of rheumatoid arthritis."JOURNAL OF ETHNOPHARMACOLOGY".2024 Aug;330:118268 88. [IF=7] Minghui Dong et al."Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway."Antioxidants".2024 Apr;13(4):445 87. [IF=10.2] Xilong Cui et al."Charge Adaptive Phytochemical-based Nanoparticles for Eradication of Methicillin-Resistant Staphylococcus aureus Biofilms."Asian Journal of Pharmaceutical Sciences".2024 Apr;:100923 86. [IF=3.4] Han Yuxuan et al."Physicochemical parameters combined with sensory and discriminant regression, for quality and sensory characterization of licorice for both food and medicine."Journal of Food Measurement and Characterization".2024 Mar;:1-10 85. [IF=4.1] Jingjing Shi et al."Differentiation of isomeric chalcone and dihydroflavone using liquid chromatography coupled with hydrogen-deuterium exchange tandem mass spectrometry (HDX-MS/MS): An application for flavonoids-focused characterization of Snow chrysanth 84. [IF=3.4] Jiaxin Yin et al."Comprehensive multicomponent characterization and quality assessment of Xiaoyao Wan by UPLC-Q-Orbitrap-MS, HS-SPME-GC-MS and HS-GC-IMS."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2024 Feb;239:115910 83. [IF=5.4] Xinxin Wu et al."The therapeutic efficacy and mechanism action of Si Cao formula in the treatment of psoriasis: A pilot clinical investigation and animal validation."JOURNAL OF ETHNOPHARMACOLOGY.2024 Apr;323:117662 82. [IF=3.4] Siyue Li et al."Spectrum-effect relationship analysis based on HPLC-FT-ICR-MS and multivariate statistical analysis to reveal the pharmacodynamic substances of Ling-Gui-Zhu-Gan decoction on Alzheimer's disease."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANAL 81. [IF=5.5] Chen Xuechun et al."Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity."Biology Direct.2023 Dec;18(1):1-19 80. [IF=4.9] Zhang Min et al."Discovery and evaluation of active compounds from Xuanfei Baidu formula against COVID-19 via SARS-CoV-2 Mpro."Chinese Medicine.2023 Dec;18(1):1-14 79. [IF=12.7] Zhongyuan Li et al."Licochalcone A plays dual antiviral roles by inhibiting RSV and protecting against host damage."JOURNAL OF MEDICAL VIROLOGY.2023 Aug;95(8):e29059 78. [IF=3.3] Jian Li et al."Rapid Analysis of 18 Flavonoids in Tea by Ultrahigh-Performance Liquid Chromatography Coupled with Quadrupole-Time of Flight Mass Spectrometry."JOURNAL OF FOOD QUALITY.2023;2023:3940081 77. [IF=5.4] Mingxiang Xie et al."Molecular mechanism of PSORI-CM01 for psoriasis by regulating the inflammatory cytokines network."JOURNAL OF ETHNOPHARMACOLOGY.2024 Jan;318:116935 76. [IF=1.7] Zhouyi Zhang et al."Revealing the differences in phenolics in different parts of Taraxacum mongolicum using UPLC-MS/MS."Phytochemistry Letters.2023 Aug;56:13 75. [IF=6.449] Yuanyue Wang et al."A novel flavonoid prenyltransferase gene PcPT11 with broad substrate promiscuity in Psoralea corylifolia L.."INDUSTRIAL CROPS AND PRODUCTS.2023 Sep;199:116746 74. [IF=7.129] Kangchen Li et al."Uncovering mechanisms of Baojin Chenfei formula treatment for silicosis by inhibiting inflammation and fibrosis based on serum pharmacochemistry and network analysis."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2023 Jul;260:115082 73. [IF=5.56] Liu Zidi et al."Abiotic factors and endophytes co-regulate flavone and terpenoid glycoside metabolism in Glycyrrhiza uralensis."APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.2023 Mar;:1-18 72. [IF=6.656] Lin Sun et al."Exploration of the anti-liver injury active components of Shaoyao Gancao decoction by network pharmacology and experiments in vivo."PHYTOMEDICINE.2023 Feb;:154717 71. [IF=4.927] Cheng-Zhu Wu et al."Isobavachalcone Induces Multiple Cell Death in Human Triple-Negative Breast Cancer MDA-MB-231 Cells."MOLECULES.2022 Jan;27(20):6787 70. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199 69. [IF=4.52] Boran Ni et al."Isoliquiritigenin attenuates emodin-induced hepatotoxicity in vivo and in vitro through Nrf2 pathway."COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY.2022 Nov;261:109430 68. [IF=3.614] Huanyu Guan et al."Deciphering the chemical constituents of Shengjiang Xiexin decoction by ultra-high-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry and the impact of 20 characteristic components on multidrug resis 67. [IF=5.988] Aijun Zhang et al."Investigation of the Pharmacological Effect and Mechanism of Jinbei Oral Liquid in the Treatment of Idiopathic Pulmonary Fibrosis Using Network Pharmacology and Experimental Validation."Frontiers in Pharmacology.2022; 13: 919388 66. [IF=2.63] Sun Ke-han et al."Comparative Pharmacokinetics of Seven Major Compounds in Normal and Atherosclerosis Mice after Oral Administration of Simiao Yong’an Decoction."Evidence-based Complementary and Alternative Medicine. 2022;2022:4604601 65. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure–Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426 64. [IF=4.57] Liu Jinyue et al."Identification and characterization of unique 5-hydroxyisoflavonoid biosynthetic key enzyme genes in Lupinus albus."Plant Cell Reports. 2021 Dec 01 63. [IF=2.629] Li Baolin et al."Phytochemical Analysis Using UPLC-MS/MS Combined with Network Pharmacology Methods to Explore the Biomarkers for the Quality Control of Lingguizhugan Decoction."Evid-Based Compl Alt. 2021;2021:7849032 62. [IF=5.34] Lin Yang et al."Isoliquiritigenin alleviates diabetic symptoms via activating AMPK and inhibiting mTORC1 signaling in diet-induced diabetic mice."Phytomedicine. 2022 Apr;98:153950 61. [IF=4.821] Shuting Xu et al."Comprehensive quality evaluation of compound bismuth aluminate tablets by multiple fingerprint profiles combined with quantitative analysis and antioxidant activity."Microchem J. 2022 May;176:107237 60. [IF=4.36] Shasha Kong et al."Synergistic mechanism for the bioactivity fortification of licorice by honey."J Ethnopharmacol. 2022 May;289:115048 59. [IF=5.545] Yuxuan Han et al."Multi-dimensional "projection" - the impact of abiotic stresses on the content of seven active compounds and expression of related genes in Glycyrrhiza uralensis Fisch."Environ Exp Bot. 2022 May;197:104846 58. [IF=5.165] Juanning Ren et al."Qualitative and quantitative analysis of multi-components in Xing-Su-Ning Capsules for quality improvement."Arab J Chem. 2022 Jun;15:103825 57. [IF=1.524] Zhang Xiaodong et al."Gene polymorphism of chalcone isomerase influence the accumulation of flavonoids in licorice (Glycyrrhiza spp.)."Genet Resour Crop Ev. 2021 Mar;68(3):899-913 56. [IF=1.813] Jin Haifeng et al."Isoliquiritigenin Attenuates Monocrotaline-Induced Pulmonary Hypertension via Inhibition of the Inflammatory Response and PASMCs Proliferation."Evid-Based Compl Alt. 2019;2019:4568198 55. [IF=1.813] Wang Yuhua et al."Isoliquiritigenin Attenuates Anxiety-Like Behavior and Locomotor Sensitization in Rats after Repeated Exposure to Nicotine."Evid-Based Compl Alt. 2020;2020:9692321 54. [IF=1.885] Xia Wenxin et al."Study on the Spectrum-Effect Relationship of the Traditional Effect of Saponins in Glycyrrhiza uralensis Fisch."Int J Anal Chem. 2021;2021:6617033 53. [IF=2.629] Li Tingting et al."Quality Assessment of Licorice Based on Quantitative Analysis of Multicomponents by Single Marker Combined with HPLC Fingerprint."Evid-Based Compl Alt. 2021;2021:8834826 52. [IF=2.633] Ruoke Ma et al."Variation of Chemical Components in Sapwood, Transition Zone, and Heartwood of Dalbergia odorifera and Its Relationship with Heartwood Formation."Forests. 2021 May;12(5):577 51. [IF=3.69] Qian Zhang et al."Qishen Granule alleviates endoplasmic reticulum stress-induced myocardial apoptosis through IRE-1-CRYAB pathway in myocardial ischemia."J Ethnopharmacol. 2020 Apr;252:112573 50. [IF=4.36] Li-Mei Feng et al."An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropathic pain by the combination of partial least-squares regression and multi-index comprehensive method."J Ethnopharmacol. 2020 Oc 49. [IF=4.36] Li Lin et al."Study on the alleviation of Fengshi Gutong capsule on rheumatoid arthritis through integrating network pharmacology and experimental exploration."J Ethnopharmacol. 2021 Nov;280:114471 48. [IF=4.879] Yang Liu et al."UV-B Radiation Largely Promoted the Transformation of Primary Metabolites to Phenols in Astragalus mongholicus Seedlings."Biomolecules. 2020 Apr;10(4):504 47. [IF=5.64] Ting Li et al."Dynamic Changes in Endophytic Microorganisms and Metabolites During Natural Drying of Licorice."Front Microbiol. 2021; 12: 740721 46. [IF=5.81] Sun Xiaoya et al."The Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Pinostrobin in Rats: Ultra-High-Performance Liquid Chromatography Coupled With Linear Trap Quadrupole Orbitrap Mass Spectrometry Studies."Front Pharmacol. 2020 Nov; 45. [IF=6.953] Dan Jiang et al."Molecular cloning and functional characterization of UGTs from Glycyrrhiza uralensis flavonoid pathway."Int J Biol Macromol. 2021 Dec;192:1108 44. [IF=11.413] Yan Yin et al."De novo biosynthesis of liquiritin in Saccharomyces cerevisiae."Acta Pharm Sin B. 2020 Apr;10:711 43. [IF=1.902] Zilingyun Wang et al."Validation of an LC–MS/MS method for simultaneous detection of diverse components of Qinxing Qingre Zhike Granule in rat plasma and its application to pharmacokinetic study after oral administration to rats."Biomed Chromatogr. 2019 J 42. [IF=1.902] Jia-Kai Zeng et al."Simultaneous quantification of multiple components in rat plasma by UPLC-MS/MS and pharmacokinetic study after oral administration of Huangqi decoction."Biomed Chromatogr. 2018 May;32(5):e4178 41. [IF=1.902] Tianming Wang et al."Simultaneous quantification of catechin, epicatechin, liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, piperine and glycyrrhetinic acid in rat plasma by HPLC-MS/MS: application to a pharmacokinetic study of Longhu Rendan 40. [IF=2.629] Fu Yuhang et al."Pharmacokinetics and Tissue Distribution Study of Pinosylvin in Rats by Ultra-High-Performance Liquid Chromatography Coupled with Linear Trap Quadrupole Orbitrap Mass Spectrometry."Evid-Based Compl Alt. 2018;2018:4181084 39. [IF=2.896] Hui-Long Luo et al."A systematic quality control method of Huangqi decoction: simultaneous determination of eleven flavonoids and seven triterpenoid saponins by UHPLC-MS."Anal Methods-Uk. 2014 Jun;6(13):4593-4601 38. [IF=2.896] Tian-Ming Wang et al."Simultaneous determination of 14 major components in Longhu Rendan pills by ultra-high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry."Anal Methods-Uk. 2014 Apr;6(9):2923-2929 37. [IF=2.985] Dan Xiong et al."Isoliquiritigenin alleviated the Ang II-induced hypertensive renal injury through suppressing inflammation cytokines and oxidative stress-induced apoptosis via Nrf2 and NF-κB pathways."Biochem Bioph Res Co. 2018 Nov;506:161 36. [IF=3.17] Biyan Zhang et al."Antineoplastic activity of isoliquiritigenin, a chalcone compound, in androgen-independent human prostate cancer cells linked to G2/M cell cycle arrest and cell apoptosis."Eur J Pharmacol. 2018 Feb;821:57 35. [IF=3.361] Huanyu Guan et al."Comparative intestinal bacteria-associated pharmacokinetics of 16 components of Shengjiang Xiexin decoction between normal rats and rats with irinotecan hydrochloride (CPT-11)-induced gastrointestinal toxicity in vitro using salting-out 34. [IF=3.361] Li Ma et al."Characterization of the global metabolic profile of liquiritin in rat plasma, urine, bile and feces based on UHPLC-FT-ICR MS."Rsc Adv. 2018 Feb;8(11):5945-5952 33. [IF=4.411] Jifeng Gu et al."Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements."Molecules. 2018 Apr;23(4):884 32. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084 31. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084 30. Luo, Hui-Long, et al. "A systematic quality control method of Huangqi decoction: simultaneous determination of eleven flavonoids and seven triterpenoid saponins by UHPLC-MS." Analytical Methods 6.13 (2014): 4593-4601. 29. Li-Mei Feng, Yan-Yan Chen, Ding-Qiao Xu, Rui-Jia Fu, Shi-Jun Yue, Qi Zhao, Yu-Xi Huang, Xue Bai, Mei Wang, Li-Ming Xing, Yu-Ping Tang, Jin-Ao Duan, An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropa 28. Li-Mei Feng, Yan-Yan Chen, Ding-Qiao Xu, Rui-Jia Fu, Shi-Jun Yue, Qi Zhao, Yu-Xi Huang, Xue Bai, Mei Wang, Li-Ming Xing, Yu-Ping Tang, Jin-Ao Duan, An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropa 27. Wang, Yuhua, et al. "Isoliquiritigenin Attenuates anxiety-like behavior and locomotor sensitization in rats after repeated exposure to nicotine."?Evidence-Based Complementary and Alternative Medicine?2020 (2020).https://doi.org/10.1155/2020/9692321 26. Jin, Haifeng, et al. "Isoliquiritigenin attenuates monocrotaline-induced pulmonary hypertension via inhibition of the inflammatory response and PASMCs proliferation." Evidence-based Complementary and Alternative Medicine 2019 (2019).https://doi.org/10.1155 25. Lin, Yuliang, et al. "Isoliquiritigenin inhibits the proliferation and induces the differentiation of human glioma stem cells."?Oncology reports?39.2 (2018): 687-694. https://doi.org/10.3892/or.2017.6154 24. Yuhang Fu, Xiaoya Sun, Lili Wang, Suiqing Chen, "Pharmacokinetics and Tissue Distribution Study of Pinosylvin in Rats by Ultra-High-Performance Liquid Chromatography Coupled with Linear Trap Quadrupole Orbitrap Mass Spectrometry", Evidence-Based Complement 23. Wang, T., Ding, L., Jin, H., Shi, R., Li, Y., Wu, J., Li, Y., Zhu, L., and Ma, Y. (2016) Simultaneous quantification of catechin, epicatechin, liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, piperine and glycyrrhetinic acid in rat plasma by H 22. Ma, Li, et al. "Characterization of the global metabolic profile of liquiritin in rat plasma, urine, bile and feces based on UHPLC-FT-ICR MS." RSC advances 8.11 (2018): 5945-5952.https://doi.org/10.1039/C7RA12529A 21. 紀(jì)萬(wàn)里,周澤華,王婷婷,安叡,梁琨,王新宏.基于UPLC-LTQ-Orbitrap-MS方法分析半夏瀉心湯化學(xué)成分[J].藥物分析雜志,2020,40(10):1736-1750. 20. 薛夢(mèng)潔,于卉娟,王璐瑤,柴欣,楊靜,王躍飛.血府逐瘀湯提取過(guò)程中成分的量變規(guī)律研究[J].天津中醫(yī)藥,2021,38(01):109-112. 19. 蔡淑慧,趙華聰,賈萌,趙曉莉,池玉梅,張?chǎng)?王洪蘭,狄留慶.基于HPLC指紋圖譜和多成分定量分析的炒甘草飲片質(zhì)量評(píng)價(jià)研究[J].中國(guó)中藥雜志,2021,46(01):118-124. 18. 丁寧,海燕,王曉暉,屠鵬飛,高博聞,史社坡.白木香查爾酮異構(gòu)酶基因的克隆鑒定與表達(dá)分析[J].藥學(xué)學(xué)報(bào),2021,56(02):630-638. 17. 洪萌,李權(quán)達(dá),石榮先.異甘草素通過(guò)調(diào)節(jié)VEGFA/NF-κB通路抑制高糖誘導(dǎo)的ARPE-19細(xì)胞增殖、遷移[J].中成藥,2020,42(10):2616-2621. 16. 余穎, 樊金玲, 程源斌,等. 甘草酸提取廢液α-葡萄糖苷酶抑制劑的篩選與鑒定[J]. 食品科學(xué), 2018, 39(13). 15. 程麗娜, 曹世杰, 曲明,等. 甘草主要成分改善L6大鼠成肌細(xì)胞胰島素抵抗的機(jī)制[J]. 中國(guó)實(shí)驗(yàn)方劑學(xué)雜志, 2020(4). 14. 董婷, 周建良, 趙維良,等. 基于指紋圖譜的銀翹解毒顆粒質(zhì)量評(píng)價(jià)[J]. 中國(guó)現(xiàn)代應(yīng)用藥學(xué), 2018, 35(09):68-72. 13. 劉效栓,肖正國(guó),羅燕燕,李喜香,李季文,畢映燕,劉軍剛.基于指紋圖譜與一測(cè)多評(píng)技術(shù)分析化學(xué)轉(zhuǎn)化法富集甘草藥渣總黃酮的研究[J].中國(guó)中醫(yī)藥信息雜志,2018,25(01):69-73. 12. 劉杰 何鋼 劉賢桂 等. 人工栽培雞血藤中五種黃酮類物質(zhì)含量測(cè)定[J]. 分子植物育種 2017 015(009):3832-3837. 11. 姜拓之, 荔志云, 孫紅軍,等. 異甘草素誘導(dǎo)人膠質(zhì)瘤細(xì)胞SHG44自噬及凋亡的實(shí)驗(yàn)研究[J]. 甘肅中醫(yī)藥大學(xué)學(xué)報(bào), 2015, 032(003):1-6. 10. 孫紅軍, 林瑜亮, 黨瑩,等. 異甘草素聯(lián)合替莫唑胺對(duì)SHG44人腦膠質(zhì)瘤干細(xì)胞增殖的影響[J]. 中華神經(jīng)外科疾病研究雜志, 2016(5):405-409. 9. 張忠斌,李艷華,沈洪寬,伍哲霖,鄭思迪,馬金鑫,丁文雅.異甘草素納米制劑的制備及其性質(zhì)分析[J].黑龍江畜牧獸醫(yī),2020(13):128-131. 8. 楊永明, 荔志云, 季瑋. 異甘草素對(duì)創(chuàng)傷性腦損傷大鼠血清細(xì)胞因子的影響[J]. 神經(jīng)損傷與功能重建, 2014(2):108-110. 7. 楊永明, 荔志云. 異甘草素對(duì)創(chuàng)傷性腦損傷大鼠神經(jīng)保護(hù)作用的實(shí)驗(yàn)研究[J]. 實(shí)用臨床醫(yī)藥雜志, 2014. 6. 楊永明, 荔志云. 異甘草素對(duì)創(chuàng)傷性腦損傷大鼠損傷灶修復(fù)作用的實(shí)驗(yàn)研究[J]. 創(chuàng)傷外科雜志, 2014, 16(2):144-146. 5. 張善強(qiáng), 李雪梅, 姚立杰,等. 異甘草素對(duì)低氧誘導(dǎo)的大鼠肺動(dòng)脈結(jié)構(gòu)重建的影響[J]. 解剖學(xué)報(bào), 2018, 049(004):492-496. 4. 姚立杰, 王月飛, 李永濤,等. 異甘草素對(duì)低氧誘導(dǎo)的大鼠肺動(dòng)脈平滑肌細(xì)胞增生的抑制作用研究[J]. 系統(tǒng)醫(yī)學(xué), 2017, v.2;No.32(20):16-19. 3. 覃月穆, 姜澤群, 馬艷霞,等. 異甘草素對(duì)人肺癌細(xì)胞株H460增殖,凋亡及NF-κB信號(hào)通路的影響[J]. 天然產(chǎn)物研究與開發(fā), 2018, 030(005):847-855. 2. 荔志云,孫紅軍,周杰,林瑜亮,黨瑩,孫建軍,李長(zhǎng)棟,黃燕萍.異甘草素對(duì)SHG44人腦膠質(zhì)瘤干細(xì)胞增殖和分化的影響[J].國(guó)際神經(jīng)病學(xué)神經(jīng)外科學(xué)雜志,2017,44(03):241-246. 1. 林瑜亮, 黨瑩, 孫紅軍,等. 異甘草素增加人腦膠質(zhì)瘤干細(xì)胞放射敏感性的實(shí)驗(yàn)研究[J]. 中國(guó)腫瘤臨床, 2017(44):1120-1124.